Micky van de Ven emerged as the first backline player to score two goals in a English top-flight match for Tottenham since Jan Vertonghen in spring 2013.
Key points
Micky Van de Ven nods home twice in first half
The home side's defender has goal ruled after video check
Senegalese midfielder nets final goal in dying moments
This loss is the Merseyside club's initial at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Tottenham prolonged their winning streak on the road in the Premier League and delivered Everton their initial loss at Hill Dickinson Stadium.
The Toffees were unbeaten in their five previous fixtures at their new ground at the dockside location, having left Goodison Park behind after more than a century at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman pounced twice from set-pieces in the first half to put their impressive record at risk, and they were unable to mount a comeback before Pape Matar Sarr - assisted by ex-Everton forward the Brazilian - nodded in a third to seal the victory.
Jake O'Brien believed he had equalized the tally a short while after Van de Ven's first goal, directing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, in the meantime, missed a handful of opportunities, while Vicario made a succession of excellent saves to guarantee the London club went five matches on the road unbeaten in the English top flight.
But the video assistant referee intervened, instructing the match official to review the score on the pitchside monitor and the referee decided that Jack Grealish and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
This victory moves Thomas Frank's side up to third in the Premier League, five points off north London rivals and table-toppers the Gunners.
Everton remain in 14th position and are six points clear of the drop zone.
Following a drab midweek performance in the Champions League against the French side, where they managed a only two shots on target, the manager chose Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The new arrival was unable to influence the game before being replaced for the substitute after an hour on the pitch, but it turns out he proved unnecessary in the end.
Defender Van de Ven transformed into an attacking force to be reckoned with.
Spurs' opening strike came from a cleverly executed corner routine, with Rodrigo Bentancur heading the ball back across the face of goal for an free the defender to score.
And Ven de Ven - stepping up as skipper in the Argentine's absence - added his second in first-half stoppage time as he outjumped Jordan Pickford to head home.
The Dutchman was equally impressive in defensive duties, combining well with his defensive colleague as the duo handled excellently with the 34 crosses thrown their way by Everton.
The club's new home had been a fortress, but it seems the freshness may have faded slightly and fans flocked to the gates after Sarr's final goal for Tottenham.
The end in Everton's winning streak at home will not be a major worry for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Everton's pair of recognised strikers - had netted just one league goal between them before Sunday's match.
And they were unable to add to that poor tally on a wet and gloomy evening on Merseyside.
The striker's performance was summed up when he chose to overhead kick a clear chance from close range, despite having room and time to readjust for a simpler shot that would have challenged Vicario.
The substitute, as well, failed to influence the game after replacing the starter in the 65th minute.
It was not for a shortage of chance. The majority of the home side's attacks came through the winger and the forward, who relentlessly whipped dangerous crosses into the Spurs box.
The Toffees: The team travel to Sunderland in the top flight on Monday, 3 November at 8 PM.
Spurs: Spurs go to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup match against the Magpies.
Elena Vance is a seasoned journalist and tech enthusiast, known for her insightful analysis and engaging storytelling across various media platforms.